Taulupe Faletau played his final game at Rodney Parade for Newport Gwent Dragons before a big-money summer move to Bath - but the Ospreys spoilt his farewell party with a 26-20 victory.
Sam Davies kicked 17 points as Ospreys came back from a poor first-half performance to seal a crucial Guinness Pro12 win over Edinburgh at the Liberty Stadium.
Wales scrum-half Rhys Webb made a successful return from injury as the Ospreys won 21-17 to become the first team to beat Munster in Cork since January 2013.
Substitute Sam Davies delivered a commanding performance as the Ospreys fought back superbly to floor French heavyweights Clermont Auvergne in stunning fashion at the Liberty Stadium.
Ospreys saw off a second-half comeback from Newport Gwent Dragons to clinch a hard-fought 12-7 Guinness PRO12 win and make it two Welsh derby victories out of two in the space of six days.
The Ospreys claimed their 12th win in 15 games over the Scarlets, winning an entertaining Guinness PRO12 derby 27-26 in Llanelli – re-vitalising their play-off hopes.
Ospreys' second-half comeback proved in vain but they still collected two losing bonus points in a 33-27 defeat at Bordeaux-Begles to keep their hopes of qualifying for the European Champions Cup quarter-finals alive.
Dan Biggar scored all 19 points to keep Ospreys joint top of Pool Two in the European Champions Cup, but it was an unconvincing performance from the hosts.
After just two rounds of European rugby this season, including some teams having only played a solitary game, the prognosis is already dire for the Guinness PRO12 sides.