The French side have already dispatched Saracens twice in this season's Champions Cup but Harlequins head to Bordeaux undeterred in their quest for victory.
Harlequins have progressed to the quarter-finals of the Investec Champions Cup as they edge out Glasgow Warriors 28-24 in the round of 16 clash at Twickenham Stoop on Friday.
Glasgow head coach Franco Smith wants his side to maintain consistency as they face Harlequins in the round of 16 Investec Champions Cup game against Harlequins on Friday at Twickenham Stoop.
Despite apologising for an officiating mistake that allowed Harlequins' lock, Irné Herbst, to return to the field early after receiving a yellow card, the Rugby Football Union has upheld Harlequins' narrow victory over Bath.
Theodor Dan and Sean Maitland scored double as Saracens scored a eight try riot as they trounced Harlequins 52-7 in the latest round of the Gallagher Premiership at Tottenham Hotspur Stadium on Saturday.
Harlequins have announced that South Africa international Andre Esterhuizen will leave the Gallagher Premiership club at the end of the ongoing season.
Jarrod Evans missed the decisive conversion at the end as Harlequins were edged out with a one point margin by Leicester Tigers in the latest round of the Gallagher Premiership at Twickenham Stoop on Friday.
Ulster have missed out on the qualification to the round of 16 in the ongoing Investec Champions Cup as they were defeated by Harlequins 47-19 at Twickenham Stoop on Saturday.
Harlequins have moved to the top of the Gallagher Premiership as they defeated Newcastle Falcons 24-3 in the latest round of the Gallagher Premiership at Kingston Park on Friday.
Bath managed to hold off Harlequins as they secured a 25-17 victory in the ninth round of the Gallagher Premiership at The Recreation Ground on Saturday.
Harlequins overcame a hat-trick from Nolann Le Garrec as they edged out Racing 92 in the opening round of the Investec Champions Cup at Paris La Defense Arena.
Will Joseph scored a double as Harlequins registered a convincing 36-3 victory in the eighth round of the Gallagher Premiership at Twickenham Stoop on Friday.
Sale Sharks director of rugby Alex Sanderson has made one change to the starting line up for the eighth round of the Gallagher Premiership clash against Harlequins to be played at Twickenham Stoop on 2nd December.