With fourth place still up for grabs, Northampton, Harlequins and Bath could all claim the final play-off spot. Also, Newcastle Falcons will play their final game in the Premiership after being relegated last time out against Gloucester.
In his latest column for Talking Rugby Union, Simon Hammersley discusses relegation from the Premiership, why Newcastle Falcons have struggled this term, the chance the Championship offers and signing off in style.
London Irish have bolstered their front row options ahead of their Premiership return after securing the signing of prop Will Goodrick-Clarke from Championship side Richmond.
Leicester have confirmed that Australia international Matt Toomua has been released from the contract early and will miss the side's final round clash in the Gallagher Premiership against Bath Rugby.
Six players including England and Bath wing Joe Cokanisiga have been named as nominees for the Land Rover Discovery of the Season by Premiership Rugby.
Bath Rugby have kept their hope of finishing in the top six alive with a 29-17 win over Wasps in their Gallagher Premiership encounter at Recreation Ground on Sunday,
Alex Lewington and Dominic Morris scored doubles as Saracens trounced Exeter Chiefs 38-7 in their Gallagher Premiership encounter at Allianz Park on Saturday.