Wasps fly-half Jimmy Gopperth is set to be sidelined for between six to nine months after he has undergone an ACL reconstruction last week.
The 35-year-old sustained the injury during the club's pre-season friendly against Connacht and is now set to undergo a lengthy rehabilitation period.
This is Gopperth's second major injury in two seasons after he spent over 10 weeks after suffering a MCL knee injury last season.
Apart from Gopperth, the Ricoh Arena outfit will also miss the services of prop Jake Cooper-Woolley for six to eight weeks after undergoing surgery on a bicep rupture that he suffered during the training camp in Portugal.
Meanwhile, hooker TJ Harris is also among the casualty list and will miss between four to six weeks of action after undergoing a surgery on a bicep rupture.
Wasps will kick-start the 2018/19 season of the Gallagher Premiership with a clash against Worcester Warriors at Sixways on 1st September.