England will be looking for a response and a much-needed boost when Wales visit Twickenham while Scotland will be aiming to build on last weekend's excellent victory against France.
England head coach Steve Borthwick has made 11 changes to the side ahead of their second World Cup warm-up fixture against Wales at Twickenham Stadium.
After a more than encouraging display against England last week, Wales boss Warren Gatland has changed his entire lineup for their trip to Twickenham and the gauntlet has been thrown down to his players.
Interview: Four-time Premiership winner and TNT Sports pundit shares his thoughts on Steve Borthwick's current squad ahead of England's opening World Cup warm-up game against Wales.
England head coach Steve Borthwick has named uncapped Northampton Saints back row Tom Pearson in the starting line up for the upcoming Rugby World Cup warm-up game against Wales to be played in Cardiff.
Leigh Halfpenny is set to make his 100th appearance for Wales as Warren Gatland has unveiled the matchday squad for their Rugby World Cup warm-up game against England to be played in Cardiff.
The winger feels Warren Gatland will have Wales in the best possible shape ahead of the Rugby World Cup with Adams drawing comparisons between the current squad and the side which reached the semi-finals four years ago.
Wales suffered a heartbreaking one-point defeat against New Zealand in their opening game of the U20s World Championship but the disappointment may well be outweighed by the positives.
Australia head coach Eddie Jones insisted that the Wallabies will not be taking Wales lightly when the two teams lock horns with each other in the Pool C Rugby World Cup clash in September.
Wales scrum-half Rhys Webb becomes the latest player to announce retirement from international rugby ahead of the Rugby World Cup scheduled later this year in France.
Exclusive interview: Welsh international chats to TRU's James Skeldon about the state of the game in his country, the retirements of Alun Wyn Jones and Justin Tipuric, recovering from injury and representing the Barbarians.
Their progression since the arrival of professional contracts has been encouraging and despite England putting another 50 points on an opposition, there are still positives to take for Wales.