Steve Tandy has made three changes - including Dan Edwards' return to fly-half - as Wales look to produce a “competitive performance” in their Guinness Six Nations clash against Ireland on Friday night.
England head coach Steve Borthwick has made nine changes to his starting XV for the Six Nations clash against Italy in Rome, with Fin Smith handed a starting role at fly-half.
Wales have confirmed the appointment of Peter Murchie as their new defence coach, ending an eight-month wait to fill the position on a permanent basis.
France overcame a determined Italian side to secure a 33-8 victory in Lille, maintaining control of their campaign despite facing their sternest test so far.
Ireland head coach Andy Farrell says his side are prepared for a demanding challenge at Twickenham as they face England in a pivotal Six Nations fixture.