Wales scrum-half Rhys Webb made a successful return from injury as the Ospreys won 21-17 to become the first team to beat Munster in Cork since January 2013.
South Africa-born flanker CJ Stander will make his international debut for his adopted Ireland in Sunday's RBS 6 Nations opener against Wales, with Sean O'Brien and Rob Kearney joining a further seven Irish stars ruled out the game with injury.
Munster have convinced winger Simon Zebo to turn down a move to France and the Top 14, with the Ireland international instead committing his future to Thomond Park until June 2018.
Munster managed to salvage some pride from what has been an immensely disappointing Champions Cup campaign with a 26-13 bonus point win over Stade Francais at Thomond Park.
Despite being down to 14 men for over forty minutes against Munster, Stade Francais all but secured their place in the Champions Cup quarter-finals with a comprehensive 27-7 victory in Paris.
Munster halted their five-game losing run and completed the double over Ulster this season by beating their interprovincial rivals 9-7 on Saturday to stay in touch with the leading sides in the Guinness PRO12.
Munster fell to their fifth straight defeat in all competitions as Zane Kirchner's last-minute intercept try sealed a 24-7 win for Leinster at Thomond Park.
After just two rounds of European rugby this season, including some teams having only played a solitary game, the prognosis is already dire for the Guinness PRO12 sides.
Simon Zebo scored a late try to secure a bonus point for Munster as they beat Benetton Treviso 32-7 at Thomond Park in their opening European Rugby Champions Cup game.
