Ireland international Keith Earls has been sidelined for up to six weeks following a knee injury that he sustained in the Grand Slam winning final round Six Nations Championship encounter against England.
The 30-year-old played 73 minutes in the encounter at Twickenham Stadium which Ireland went on to win 15-24.
A statement released by Munster confirmed that Earls is expected to be out of action for six weeks which puts him out of contention for the club's European Champions Cup knock out game against Toulon in Limerick on Saturday.
He could be also in doubt for the semi-final if the Irish provincial side emerges victorious against the French giants.
Earls is also expected to miss the remainder of the league games for Munster in Pro 14 but should be available for the play-off games.
Meanwhile, Peter O'Mahony, CJ Stander and Conor Murray, who were rested last Saturday from their club duties are set to return to training.