The French side have already dispatched Saracens twice in this season's Champions Cup but Harlequins head to Bordeaux undeterred in their quest for victory.
Harlequins have progressed to the quarter-finals of the Investec Champions Cup as they edge out Glasgow Warriors 28-24 in the round of 16 clash at Twickenham Stoop on Friday.
Baxter and Harlequins coach Danny Wilson are targeting a piece of history when they meet Glasgow in the Champions Cup this weekend.