Brunel has retained his faith on the side that defeated Argentina 28-13 last weekend. Full back Maxime Medard drops out of the matchday23 squad as Benjamin Fall takes his place.
The second and final change sees tight-head prop Cedate Gomes Sa making way for Rabah Slimani as he earns a promotion from the bench.
Slimani and Fall's places on the bench has been taken by Demba Bamba and Geoffrey Doumayrou respectively. Apart from Bamba, Julien Marchand is also set to make his debut for France after included in the replacement list.
The game on Saturday will be 10th Test between these two sides with France claiming wins on all the previous nine occasions.
France: Benjamin Fall, Teddy Thomas, Mathieu Bastareaud, Gael Fickou, Yoann Huget, Camille Lopez, Baptiste Serin, Louis Picamoles, Artur Iturria, Wenceslas Lauret, Yoan Maestri, Sebastien Vahaamahina, Rabah Slimani, Guilhem Guirado (c), Jefferson Poirot
Replacements: Julien Marchand, Dany Priso, Demba Bamba, Felix Lambey, Kélian Galletier, Antoine Dupont, Anthony Belleau, Geoffrey Doumayrou