England head coach Steve Borthwick has made nine changes to his starting XV for the Six Nations clash against Italy in Rome, with Fin Smith handed a starting role at fly-half.
Fiji will stage their home fixtures in the inaugural Nations Championship in Cardiff, Liverpool and Edinburgh, for the Nations Championship clashes against Wales, England and Scotland respectively.
Ireland head coach Andy Farrell says his side are prepared for a demanding challenge at Twickenham as they face England in a pivotal Six Nations fixture.
France climbed above England in the latest World Rugby rankings after another strong Six Nations performance, while Scotland also improved their position following a key victory.
Scotland ended England’s long winning run with a 31-20 victory at Murrayfield, producing a clinical attacking display backed by determined defence to keep the Calcutta Cup in Edinburgh.
The England World Cup winner says she didn’t move back to the North-West to sit in the lower reaches of the PWR table but believes Sale have the foundations to grow on and off the pitch.
England wing Immanuel Feyi-Waboso has been ruled out of Saturday's match against Scotland and is facing a race against time to feature in the Six Nations after suffering a hamstring injury.