Gloucester's Owen Williams will miss the remainder of the Six Nations tournament for Wales following a hamstring injury.
The 27-year-old sustained the blow ahead of Wales' second round clash against Ireland last weekend in Dublin and was replaced by Jarrod Evans in the bench.
"Further assessment has concluded that the injury will rule Williams out of the remainder of Wales' Guinness Six Nations campaign," read a statement released by the Welsh Rugby Union.
Williams made his debut for Wales in 2017 and has gone on to play three Tests - with all of it coming that year and has endured tough times with injuries since then.
Fullback Liam Williams continues to be on the sidelines after failing to make sufficient recovery from an ankle injury that he suffered during the World Cup campaign last year while Josh Adams is recovering from a hip injury.
Wales currently are at the third position in the Six Nations table with a win and a defeat apiece in two games and will lock horns with France next at Principality Stadium on 22nd February.