Ospreys wing George North is set to make his 100th Test appearance for Wales after being part of the starting line-up for the third round clash against England at Principality Stadium.
North, who made his debut for Wales in 2010 missed the previous game against Scotland and is slotted at 13 and partners with Jonathan Davies, who also makes a comeback from an injury.
Liam Williams makes a switch to fullback allowing Louis Rees-Zammit partner with Josh Adams at wing. Kieran Hardy returns at scrum-half forming half-back partnership with Dan Biggar.
The front and second rows remain unchanged while the backrow sees a change with Aaron Wainwright replaced by Josh Navidi.
“We’ve had a great two weeks leading into this game and we are looking forward to Saturday,” said Pivac.
“We continue to build and we know there is plenty left in us in terms of improvements from the opening two rounds. We are 2/2 but we want to continue to improve performance wise.
“Saturday is a great milestone for George, it is a huge achievement at his age and we are looking forward to seeing him in action.”
Wales starting XV: 15 Liam Williams, 14 Louis Rees-Zammit, 13 George North, 12 Jonathan Davies, 11 Josh Adams, 10 Dan Biggar, 9 Kieran Hardy, 8 Taulupe Faletau, 7 Justin Tipuric, 6 Josh Navidi, 5 Alun Wyn Jones (c), 4 Adam Beard, 3 Tomas Francis, 2 Ken Owens, 1 Wyn Jones
Reserves: 16 Elliot Dee, 17 Rhodri Jones, 18 Leon Brown, 19 Cory Hill, 20 James Botham, 21 Gareth Davies, 22 Callum Sheedy, 23 Uilisi Halaholo