Wales head coach Wayne Pivac has named seven uncapped players in the 38-man squad for the end of the year series.
Bristol pair Callum Sheedy and Ioan Lloyd will be joined by hooker Sam Parry, back-rower Josh Macleod, scrum-half Kieran Hardy, centre Johnny Williams and wing Louis Rees-Zammit.
Sheedy also qualifies to play for England and was part of their squad in the game against Barbarians in June last year along with Johnny Williams and had also represented Ireland Under 19 in the past.
Tomas Francis, Rhys Patchell and Jonathan Davies have all returned from injuries as Wales face France in a friendly on 24th October before facing France in the final round of the Six Nations game against Scotland on 31st October at Parc y Scarlets Stadium.
Wales will also kick-start their Autumn Nations Cup campaign against Ireland on 13th November at Aviva Stadium.
"We are looking forward to getting back to international rugby and getting the squad together again," said Pivac.
"This campaign is hugely important looking to the future and long term to the Rugby World Cup in 2023.
"We kick off the campaign with a game against France which will help prepare us for the re-arranged Six Nations match versus Scotland, it's an important game and important we get a good performance.
"We then go into the Autumn Nations Cup (ANC) which is an exciting tournament and a great opportunity for us".
Wales' 38-man squad:
Forwards (21): Rhys Carre (Cardiff Blues), Wyn Jones (Scarlets), Nicky Smith (Ospreys), Ken Owens (Scarlets), Ryan Elias (Scarlets), Sam Parry (Ospreys)*, Samson Lee (Scarlets), Dillon Lewis (Cardiff Blues), Tomas Francis (Exeter Chiefs), Leon Brown (Dragons), Alun Wyn Jones (Ospreys), Will Rowlands (Wasps), Jake Ball (Scarlets), Seb Davies (Cardiff Blues), Cory Hill (Cardiff Blues), Aaron Wainwright (Dragons), Ross Moriarty (Dragons), Taulupe Faletau (Bath), Josh Navidi (Cardiff Blues), Justin Tipuric (Ospreys), Josh Macleod (Scarlets)*.
Backs (17): Rhys Webb (Ospreys), Gareth Davies (Scarlets), Kieran Hardy (Scarlets)*, Dan Biggar (Northampton), Rhys Patchell (Scarlets), Callum Sheedy (Bristol)*, Owen Watkin (Ospreys), Nick Tompkins (Dragons), Jonathan Davies (Scarlets), Johnny Williams (Scarlets)*, George North (Ospreys), Josh Adams (Cardiff Blues), Louis Rees-Zammit (Gloucester)*, Jonah Holmes (Dragons), Leigh Halfpenny (Scarlets), Ioan Lloyd (Bristol)*, Liam Williams (Scarlets).