After just two rounds of European rugby this season, including some teams having only played a solitary game, the prognosis is already dire for the Guinness PRO12 sides.
Simon Zebo scored a late try to secure a bonus point for Munster as they beat Benetton Treviso 32-7 at Thomond Park in their opening European Rugby Champions Cup game.
Replacement CJ Stander was the hero as Munster stole a 20-18 Guinness PRO12 victory in the final minute to leave Ospreys winless from their opening two matches.
Conor Murray ran in a hat-trick of tries as Munster hammered the Newport Gwent Dragons 50-27 at Irish Independent Park to book a home Guinness PRO12 play-off.
Munster skipper Peter O'Mahony accepts their European Champions Cup quarter-final qualification hopes rest in the hands of others - but he is adamant his battling side will not give up until the final whistle.
Clermont Auvergne produced a powerhouse performance at Thomond Park to beat Munster 16-9 and take over at the top of the European Rugby Champions Cup's Pool One.