The attention on Italy was only heightened after their victory over England, so Wales know they must produce another encouraging performance if they are to claim their elusive Six Nations win.
England head coach Steve Borthwick has made nine changes to his starting XV for the Six Nations clash against Italy in Rome, with Fin Smith handed a starting role at fly-half.
France overcame a determined Italian side to secure a 33-8 victory in Lille, maintaining control of their campaign despite facing their sternest test so far.
France climbed above England in the latest World Rugby rankings after another strong Six Nations performance, while Scotland also improved their position following a key victory.
Ireland avoided a shock defeat in the second round of Six Nations at the Aviva Stadium, coming from behind to defeat a spirited Italy after a tense second half comeback.
South Africa lock Lood de Jager has lost his appeal against a four-match suspension received for a red-card offence during his team’s 32-17 victory over France on 8 November.
South Africa will start with 11 changes to their starting XV for Saturday’s Autumn Series match against Italy, head coach Rassie Erasmus confirmed on Thursday.