Ireland will be without skipper Johnny Sexton for the second round of the Six Nations game against France to be played in Dublin on Sunday.
Sexton has failed to recover from a concussion that he suffered during the opening game against Wales with Ulster's Billy Burns replacing him at fly-half.
There were further injury blows to Andy Farrell's side with Conor Murray joining the injury list with a hamstring problem and Jamison Gibson-Park replaces him at scrum-half. James Ryan is also out of the encounter with a head injury with Iain Henderson taking his place in the second row and also captaining the side.
The final change sees Rhys Ruddock coming in the back row replacing the suspended Peter O'Mahony, who had a red card in the game against Wales.
The bench also has four changes with Ed Byrne, Ultan Dillane, Ross Byrne and the uncapped Craig Casey coming into the matchday 23 squad.
Ireland starting XV: Ireland: 15 Hugo Keenan, 14 Keith Earls, 13 Garry Ringrose, 12 Robbie Henshaw, 11 James Lowe, 10 Billy Burns, 9 Jamison Gibson-Park, 8 CJ Stander, 7 Josh van der Flier, 6 Rhys Ruddock, 5 Iain Henderson (c), 4 Tadhg Beirne, 3 Andrew Porter, 2 Rob Herring, 1 Cian Healy
Replacements: 16 Ronan Kelleher, 17 Ed Byrne, 18 Tadhg Furlong, 19 Ultan Dillane, 20 Will Connors, 21 Craig Casey, 22 Ross Byrne, 23 Jordan Larmour