Ireland scrum-half Jamison Gibson-Park will miss his side's final autumn international fixture against Argentina following a thigh injury.
Having made his international debut in 2020, Gibson-Park played a pivotal role in Ireland's win over New Zealand last weekend at Aviva Stadium and now becomes the second player from his side to be ruled out due to injury following skipper Johnny Sexton, who has a ankle and knee problem.
The Irish board also confirmed that James Ryan will be leading the side in next weekend's encounter in the absence of Sexton while Leinster player Luke McGrath is added to the squad as a cover.
McGrath has played 19 Tests for Ireland since his international debut in 2016 and has been recalled by the head coach Andy Farrell for the first time since his last appearance in the 2019 World Cup.
Joey Carbery is likely to start for Ireland in the game against the Pumas while Conor Murray, who came off the bench against New Zealand is set to take the scrum-half position.
Ireland will be hoping to round off their autumn international campaign undefeated after beating Japan and New Zealand with a margin of 60-5 and 29-20 respectively in the opening two matches.