Bath winger Anthony Watson will miss England's upcoming Six Nations game against Scotland after failing to recover from a calf injury.
Watson sustained the injury during the Portugal training cam ahead of the Six Nations tournament and was already ruled out of the tournament opener against France.
England forward coach Matt Proudfoot confirmed the news on the 25-year-old.
"Anthony felt it again yesterday and we won't consider him for Scotland," he said.
George Furbank made his debut for England in the game against France at fullback with Elliot Daly slotted at wing along with Jonny May but the Northampton Saints youngster endured a tough outing with the red rose team succumbing to a 24-17 defeat.
Nevertheless Proudfoot backs the 23-year-old to comeback strong in the upcoming games.
"Coaching is about helping players get better," he added.
"What do you think I'm going to do? Say: 'George you're absolute rubbish get out of here, go back to Northampton, work in the shoe factory?'
"What am I going to say to him? Of course, I'm going to help him become a better player, and I thought he was good against France."