Scotland head coach Gregor Townsend has named uncapped centre Cameron Redpath in the starting line up for the Six Nations opening game against England.
Chris Harris will partner with Redpath in midfield while Finn Russell is back in the line-up after missing the Autumn Nations Cup due to injury. Russell will form halfback partnership with Russell.
Duhan van der Merwe and Sean Maitland are positioned at wings with skipper Stuart Hogg slotted at fullback. The front-row sees Rory Sutherland, George Turner and Zander Fagerson with Scott Cummings and Jonny Gray continuing their second row partnership.
The backrow comprises of Matt Fagerson, Hamish Watson and Jamie Ritchie while Edinburgh hooker David Cherry could make his debut for the Dark Blues when he comes off the bench.
“This most historic of fixtures against England is a great start to the 2021 Guinness Six Nations and a challenge we will fully embrace with the objective of playing to our potential and ultimately lifting our supporters in these difficult times," said Townsend.
“We learned a lot about ourselves and where the game is going during our Autumn campaign, and we aim to build on this base during the next seven weeks. We are set for a huge challenge against England as we will be facing one of the best teams in the world."
Scotland XV: 15 Stuart Hogg (c), 14 Sean Maitland, 13 Chris Harris, 12 Cameron Redpath, 11 Duhan van der Merwe, 10 Finn Russell, 9 Ali Price, 8 Matt Fagerson, 7 Hamish Watson, 6 Jamie Ritchie, 5 Jonny Gray, 4 Scott Cummings, 3 Zander Fagerson, 2 George Turner, 1 Rory Sutherland
Reserves: 16 David Cherry, 17 Oli Kebble, 18 WP Nel, 19 Richie Gray, 20 Gary Graham, 21 Scott Steele, 22 Jaco van der Walt, 23 Huw Jones