England skipper Owen Farrell will be out of action for three months following an ankle injury.
Farrell sustained the blow during England's clash against Australia last weekend where he limped off the field in the 68th minute. He was already withdrawn from the squad ahead of the key clash against South Africa to be played at Twickenham Stadium on Saturday.
The news was confirmed by Farrell's club Saracens.
"Will undergo surgery for an ankle injury sustained while playing for England against Australia, is expected to be out for 10-12 weeks," the statement read.
The 30-year-old already missed the autumn international game against Tonga after he was tested positive for Covid-19 but later returned to the squad ahead of the game against Australia after his sample was found to be false positive.
Meanwhile, Saracens also revealed that hooker Jamie George, who also suffered a knee injury during the game against Australia is expected to be out of action for 8 to 10 weeks while Elliot Daly, who has been out of action since returning from Lions' tour of South Africa has returned to training and is available for selection.