A busy Christmas schedule sees Bath travel to Franklins Gardens in search of some early festive cheer, whilst the top two square off at the Stoop with Quins heroes of the battle of Toulouse hosting champions Saracens.
Welsh international forward Andy Powell is set to make his debut for Sale Sharks against Leicester Tigers in Friday's Aviva Premiership match at Edgeley Park (kick off 7.45 p.m.)
Sale Sharks fought back from being nine points down to defeat Northampton Saints 29-21 at Edgeley Park on Friday night in a game that was marred by three yellow cards.
It was predicted to be the match of the weekend and signs began proving it as early as on Monday evening when "sold out" signs were put up at Loftus Stadium ticket offices
Five years ago Sale Sharks were crowned Guinness Premiership Champions after demolishing the powerhouse of English rugby Leicester Tigers 45-20 in the final at Twickenham.
Exeter Chiefs ended a run of four straight defeats in an exciting match at Edgeley Park. The match was Charlie Hodgson's last home game for Sale Sharks