England will miss the services of Ollie Lawrence for the upcoming Autumn Nations Cup game against Wales following a hip injury.
Lawrence, who has played three Tests for the red rose team was replaced in the 69th minute during the game against Ireland and is now rested for the encounter against Wayne Pivac's men.
Northampton full-back George Furbank and Wasps fly-half Jacob Umaga are left out of selection due to injuries while Jack Willis makes a return after missing the game against Ireland.
Anthony Watson and Luke Cowan-Dickie are also part of the squad after making recovery from ankle and knee injuries respectively.
“Ollie has a little niggle around his abductor and hip area, nothing major but it is a niggle that is concerning him,” defence coach John Mitchell said.
“Ollie has huge potential as a centre. He is very talented in terms of running onto the ball and he has got exceptional ability to line break.”
England currently are at the top of the Group A in the ongoing Autumn Nations Cup after beating Georgia and Ireland in the opening two rounds.
Elliot Daly (Saracens, 45 caps)
Owen Farrell (Saracens, 86 caps)
George Ford (Leicester Tigers, 70 caps)
Jonathan Joseph (Bath Rugby, 53 caps)
Max Malins (Bristol Bears, 2 caps)
Jonny May (Gloucester Rugby, 59 caps)
Dan Robson (Wasps, 5 caps)
Henry Slade (Exeter Chiefs, 32 caps)
Anthony Watson (Bath Rugby, 44 caps)
Ben Youngs (Leicester Tigers, 102 caps)
Luke Cowan-Dickie (Exeter Chiefs, 24 caps)
Tom Curry (Sale Sharks, 26 caps)
Ben Earl (Bristol Bears, 6 caps)
Ellis Genge (Leicester Tigers, 21 caps)
Jamie George (Saracens, 52 caps)
Jonny Hill (Exeter Chiefs, 2 caps)
Maro Itoje (Saracens, 41 caps)
Joe Launchbury (Wasps, 67 caps)
Joe Marler (Harlequins, 71 caps)
Kyle Sinckler (Bristol Bears, 38 caps)
Will Stuart (Bath Rugby, 6 caps)
Sam Underhill (Bath Rugby, 20 caps)
Billy Vunipola (Saracens, 54 caps)
Mako Vunipola (Saracens, 62 caps)
Jack Willis (Wasps, 1 cap)