Leicester Tigers wing Jonah Holmes has been sidelined for up to six weeks following a partial tear to medial collateral ligament.
The 27-year-old sustained the injury during the recently concluded Gallagher Premiership game against Northampton Saints where he was replaced in the 19th minute.
The Welsh international underwent a scan following the game and now is expected to remain on the sidelines until the start of 2020.
Leicester Tigers head coach Geordan Murphy expressed disappointment on the news.
“We’re very disappointed for Jonah, he is a much valued member of this squad and it’s a cruel blow for him given the form he is in for us,” said Murphy.
“Since returning to the group part way through the pre-season programme, after spending the opening months of the summer with Wales, he has added a lot to this young group.
“His growth and improvement since joining Tigers has been huge and seen him rise from a Championship player to international.”
Holmes, who joined Leicester Tigers in 2017 has played three Tests for Wales since making his debut in 2018 with his last appearance coming during the World Cup warm-up game against Ireland in August.
Leicester Tigers had a tough start to the season as they are positioned 11th in the Gallagher Premiership table with a solitary win from four games but have revived themselves in the Challenge Cup where they won both their games to hold the top place in Pool 5.