Wales will miss the services of Cardiff Blues wing Hallam Amos for the remainder of the season following a knee injury.
The 25-year-old sustained the injury during the Pro 14 game against Benetton on 23rd February which his side went on to win 34-24.
Amos, who has played 22 Tests for Wales missed out on the initial selection for Six Nations tournament following an ankle ligament damage but went on to replace Owen Lane in the squad, who sustained a hamstring injury.
A statement read by the Welsh Rugby Union confirmed that Amos will undergo a surgery which will end his season.
"He (Amos) will have surgery and it is expected that he will also miss the remainder of the season," a Welsh Rugby Union statement read.
Wales are already without Josh Adams, who is sidelined with an ankle injury while George North will undergo return to play protocols after failing a head injury assessment during the previous game clash against France.
Wayne Pivac will also be anxious about the availability of Dan Biggar, who suffered a knee injury while representing his club Northampton Saints last weekend.
Wales are positioned fourth in the Six Nations table with a solitary win from three games and will face England and Scotland in the final two rounds on 7th and 14th March respectively.