Wales might be without the Premiership players for their autumn international fixture against New Zealand scheduled to be played on 30th October.
With the fixture falling outside the Test window, the Wales players plying their trade in England's Gallagher Premiership are set to miss the game which will be played at Principality Stadium.
It means Wales are likely to be without Dan Biggar, Callum Sheedy, Louis Rees-Zammit and Taulupe Faletau while Justin Tipuric, Leigh Halfpenny and George North are recovering from long-term injuries.
Following the game against New Zealand, Wales will also face World Champions South Africa on 6th November followed by games against Fiji and Australia on 14th and 20th November respectively.
Meanwhile, the Welsh Rugby Union are looking to welcome fans in full capacity with the Covid restrictions easing in the country which will be a huge relief for the board as they announced a loss of £5.3m for the year up to June 30, 2020 with its annual report revealing 78% of income is derived from staging Wales international matches.
Wales' Autumn International Fixtures:
30th October - Wales v New Zealand
6th November - Wales v South Africa
14th November - Wales v Fiji
20th November - Wales v Australia