England have been dealt injury blows ahead of the upcoming Six Nations with centre Ollie Lawrence and hooker Luke Cowan-Dickie withdrawing from the training squad.
Lawrence picked up the injury while playing for Bath Rugby in last weekend's Investec Champions Cup game against Toulouse while Cowan-Dickie was replaced early in the second half during Sale's defeat to La Rochelle.
Harlequins centre Oscar Beard suffered a concussion during the victory over Ulster and is undergoing return to play protocols.
According to reports, it is understood that both Lawrence and Cowan-Dickie might be doubtful for England's Six Nations opener against Italy in Rome on 3rd February.
England coach Steve Borthwick has called up Newcastle's Jamie Blamire and the Bath pair of centre Max Ojomoh and wing Will Muir to the squad as replacements.
England's updated Six Nations squad:
Forwards: Ollie Chessum, Dan Cole, Alex Coles, Jamie Blamire, Chandler Cunningham-South, Ben Curry, Theo Dan, Alex Dombrandt, Ben Earl, Ellis Genge, Jamie George (capt), Joe Heyes, Nick Isiekwe, Maro Itoje, Joe Marler, Beno Obano, Tom Pearson, Ethan Roots, Will Stuart, Sam Underhill.
Backs: Max Ojomoh, Danny Care, Elliot Daly, Fraser Dingwall, Immanuel Feyi-Waboso, George Ford, Tommy Freeman, George Furbank, Will Muir, Alex Mitchell, Tom Roebuck, Henry Slade, Fin Smith, Marcus Smith, Ben Spencer, Freddie Steward.