The hosts were struggling to get a foothold in the game and were starting to lose their discipline before the first real moment of brilliance from Macc sparked them into life.
Winger Elliot Brierley broke the Chester line before feeding Venables who superbly offloaded the ball to Fowles who darted over.
That try was the cue for Macclesfield to start turning the screw and control the tempo of the game which they have done on numerous occasions on home soil this term.
A series of sustained phases led to Macclesfield making more inroads into the Chester 22 and it was the hosts who had the last say of the half.
Superb hands from the Macclesfield backs eventually led to an overlap on the left side of the pitch as Parkinson produced a lovely pass around the corner for Venables who had the simple task of crossing in the corner to give his side the lead.
Barker converted that try in difficult weather conditions before the break, but Chester were still very much in the contest as both teams trudged off for half-time.
However, after a quick-fire start to the first 40 from Chester, it was Macc who upped the intensity in the second period, scoring four more tries.
Firstly, Parkinson barged his way over from close range from a rolling maul before Fowles burst through from midfield to dive over a secure the try-bonus point for Macclesfield which also confirmed the championship for the home side.
With the league title now in the bag, the pressure was off the Blues who continued to pile the pressure on the Chester line and following a yellow-card for a preventing a quick tap penalty, Macclesfield were awarded a Penalty Try to extend their lead to 33-7.
There was still time for the impressive Fowles to claim his hat-trick and he did with ease as he cut a beautiful line to race over and put the icing on the cake for Macclesfield who had taken charge of this second half to secure victory.
Chester did have the final say of the afternoon when they scored their second try after great work from Hayes, but the day belonged to Macclesfield.
The final whistle sparked jubilant celebrations among the Macclesfield players and support with12 months ago now a distant memory.
National Two North
Elsewhere in National Two North, Sedgley Park’s play-off hopes suffered a slight dent as they were beaten 34-19 away at Caldy while Leicester Lions moved to within nine points of Sedge after a 36-14 win at Broadstreet.
That defeat for Broadstreet confirmed their relegation from National Two North as Sale FC produced the result of the afternoon as they came away from Stourbridge with a 23-10 victory which moves them out of the bottom three, for a few hours at least.
South Leicester also boosted their survival bid with an impressive 36-21 win over Harrogate which means they could be safe from relegation if Sandal lose to Tynedale in the late kick-off.
The Luctonians continued their impressive recent form as they edged out Otley 32-28 at Cross Green, while Preston Grasshoppers confirmed their safety in style after an emphatic 57-17 win over already relegated Huddersfield.
Tynedale v Sandal is the late kick-off.
National Two South
Cambridge maintained their five point lead at the top of National Two South after a 36-15 win over Southend Saxons which saw the sea-side club relegated from the fourth tier of English rugby.
Second placed, the Old Albanian continued to put pressure on Cambridge as they beat the Old Elthamians 46-20 while Bishops Stortford triumphed 53-5 over the Redingensians and Redruth won 32-18 at home against Barnes.
Dorking have given themselves a real chance of staying in National Two South after they secured a vital 27-14 win over Bury St Edmunds. That victory leaves them just three points from safety because Worthing Raiders lost 30-12 away at Taunton Titians.
Elsewhere, Canterbury took a huge step to safety after a 34-27 win over Clifton while Chinnor confirmed their place in National Two South following a 75-3 thrashing of bottom side Launceston.