England have been dealt another injury blow ahead of the final round game against Ireland with lock Ollie Chessum ruled out of the encounter.
The 22-year-old picked up an ankle injury during a training session and has been now been sidelined for the weekend's game.
Chessum's Leicester team-mate George Martin has been called up to the squad.
Meanwhile, George Ford is set to make his first Test appearance in 12 months after proving his fitness featuring 80 minutes for his club Sale Sharks last weekend.
With Ollie Lawrence also ruled out with a hamstring injury, Manu Tuilagi is set to play his first game in the competition under Steve Borthwick.
“He is fit and ready. He’s fit to go,” said defence coach Kevin Sinfield on Ford's fitness.
“Manu has been outstanding and deserves a shot this week. He brings some physicality to us and we needed a bit more of that last weekend but we didn’t get it.
"Hopefully he will provide some of that at the weekend.”
Forwards: Dan Cole, Ben Curry, Alex Dombrandt, Tom Dunn, Ellis Genge, Jamie George, Jonny Hill, Nick Isiekwe, Maro Itoje, Lewis Ludlam, George Martin, David Ribbans, Bevan Rodd, Kyle Sinckler, Mako Vunipola, Jack Walker, Jack Willis
Backs: Henry Arundell, Owen Farrell, George Ford, Ollie Hassell-Collins, Max Malins, Joe Marchant, Alex Mitchell, Henry Slade, Marcus Smith, Freddie Steward, Manu Tuilagi, Jack van Poortvliet, Anthony Watson