England head coach Steve Borthwick has made five changes to the starting lineup for the Calcutta Cup game against Scotland, with George Furbank replacing Freddie Steward at full-back.
The Northampton Saint is set to feature in his first international Test in two years at the expense of Steward while clubmate Tommy Freeman, as well as Saracens' Elliot Daly, retain their spots on the wings.
Ollie Lawrence replaces Fraser Dingwall in the midfield where he joins Henry Slade, while George Ford continues at fly-half with Fin Smith providing cover from the bench.
Danny Care will replace the injured Alex Mitchell at scrum-half while Maro Itoje and Ollie Chessum have retained their second-row partnership.
The back row sees no change, while Dan Cole starts at tighthead with Ellis Genge at loosehead joining skipper Jamie George in the front row.
George Martin comes onto the bench for the first time since last year's World Cup semi-final - replacing Alex Coles - while there was also a recall for Bath scrum-half Ben Spencer.
"We're pleased with the start we've made to our Six Nations campaign but know that a difficult test awaits us in Edinburgh against an in-form Scotland team," said Borthwick.
"The atmosphere is always special for any Calcutta Cup match and I'm sure this weekend's game at Murrayfield will be no different.
England: 15 George Furbank, 14 Tommy Freeman, 13 Henry Slade, 12 Ollie Lawrence, 11 Elliot Daly, 10 George Ford, 9 Danny Care, 8 Ben Earl, 7 Sam Underhill, 6 Ethan Roots, 5 Ollie Chessum, 4 Maro Itoje, 3 Dan Cole, 2 Jamie George (c), 1 Ellis Genge
Reserves: 16 Theo Dan, 17 Joe Marler, 18 Will Stuart, 19 George Martin, 20 Chandler Cunningham-South, 21 Ben Spencer, 22 Fin Smith, 23 Immanuel Feyi-Waboso