Elliot Daly will make his comeback for England this Sunday, having been selected on the wing for their final autumn Test against Argentina at Allianz Stadium.
Coach Steve Borthwick has made six changes to the starting XV following their 33-19 victory over New Zealand.
Daly, who fractured his forearm while on the British & Irish Lions tour in July, returns in place of injured winger Tom Roebuck. Immanuel Feyi-Waboso makes a shift to right wing.
Also missing is Ollie Lawrence, who is sidelined by a hamstring injury. Henry Slade comes into the centre pairing alongside Fraser Dingwall.
In the front row, Luke Cowan-Dickie starts at hooker, flanked by Ellis Genge and Asher Opoku-Fordjour while Ben Spencer takes over at scrum-half from Alex Mitchell.
"Last weekend gave us plenty to build on, and now the challenge is to push our performance further," Borthwick said.
"Argentina play with emotion and physicality, and they've shown they can beat the best in world rugby this year. We know how dangerous they can be, and we are preparing for a fiercely contested Test match.
"We have felt exceptional support at Allianz Stadium throughout this series. It provides a real lift for the players, and we hope to create lasting memories for our supporters on Sunday."
England XV: 15 Freddie Steward, 14 Immanuel Feyi-Waboso, 13 Henry Slade, 12 Fraser Dingwall, 11 Elliot Daly, 10 George Ford, 9 Ben Spencer, 8 Ben Earl, 7 Sam Underhill, 6 Guy Pepper, 5 Alex Coles, 4 Maro Itoje (c), 3 Asher Opoku-Fordjour, 2 Luke Cowan-Dickie, 1 Ellis Genge
Reserves: 16 Theo Dan, 17 Fin Baxter, 18 Will Stuart, 19 Charlie Ewels, 20 Tom Curry, 21 Henry Pollock, 22 Alex Mitchell, 23 Marcus Smith