Wales will miss the services of Jake Ball and Justin Tipuric for the final game of the autumn international campaign against South Africa due to injuries.
Ball, who was replaced in the 18th minute during the previous game against New Zealand has a dislocated shoulder while Tipuric, who played the final 10 minutes in the game has a thigh injury and has returned to his club Ospreys.
Meanwhile, Rhys Webb will continue to remain with the squad and will undergo a return to play protocols after suffering a head injury in the same game at Principality Stadium last weekend.
There are also doubts on Scott Williams' participation in the game as he is recovering from an ankle injury but head coach Warren Gatland will have Bath's Taulupe Faletau available for the 2nd December's game.
Wales have suffered defeats to New Zealand and Australia while managed to defeat Georgia in their ongoing campaign which comes to a conclusion when they host Allister Coetzee's men on Saturday.