England will miss the services of Tom Curry in the upcoming autumn internationals after the Sale openside suffered a wrist dislocation.
The 19-year-old was named among the replacements for England's opening game against Argentina at Twickenham on Saturday but now is set to remain on the sidelines for up to three months.
"Following a scan this afternoon it has been confirmed that Tom Curry dislocated a small bone in his left wrist today," read a statement from Rugby Football Union.
"He underwent a minor operation this evening and is likely to be out for up to 12 weeks."
England coach Eddie Jones has named Exeter's Sam Simmonds as a replacement for Curry for the clash against the Pumas.
Jones had thought long and hard about whether or not to start Curry ahead of Sam Underhill, but went with the latter.
''We've had a good battle between Underhill and Curry. They're genuine opensides. We've got Simmonds coming through,'' Jones said.
''We've got some good back rowers coming through. It's a new generation. They're athletically good. They've got a good attitude. It's very exciting."
Following the game against Argentina, England will also take on Australia and Samoa in their November Tests campaign.