British and Irish Lions duo Owen Farrell and Maro Itoje has been rested by England coach Eddie Jones for the upcoming autumn internationals clash against Argentina at Twickenham on Saturday.
Henry Slade takes Farrell's place at inside centre with Alex Lozowski finding a place on the bench while George Kruis and Courtney Lawes team-up in the second row.
Slade starts alongside Jonathan Joseph in the midfield while Wasps wing Elliot Daly has also been handed a start following his recovery from a knee injury.
"This is our best 23 selected in what is our most important game this year," Jones said.
"We know that Argentina is a strong team - they were World Cup semi-finalists in 2015 - and we will have to be smart and play well to beat them."
Jonny May is yet to make full recovery from a hamstring problem allowing Semesa Rokoduguni find a place among the replacements.
England line-up to face Argentina:
Mike Brown; Anthony Watson, Jonathan Joseph, Henry Slade, Elliot Daly; George Ford, Ben Youngs; Mako Vunipola, Dylan Hartley (capt), Dan Cole; Courtney Lawes, George Kruis; Chris Robshaw, Sam Underhill, Nathan Hughes
Replacements: Jamie George, Ellis Genge, Harry Williams, Joe Launchbury, Tom Curry, Danny Care, Alex Lozowski, Semesa Rokoduguni