England Women head coach Simon Middleton has named seven uncapped players in the squad for the Quilter autumn internationals.
Bristol Bears duo Lucy Attwood and Ellie Mulhearn, Waterloo's No 8 Sarah Beckett and Saracens prop Ellena Perry have all been included in the squad along with Loughborough centre Carys Williams, Wasps scrum half Claudia Macdonald and Gloucester-Hartpury centre Tatyana Heard.
However, the focus will be on Katy Daley-Mclean as she is on track to make her 100th appearance for England during the series. Daley-Mclean, who led England to the 2014 World Cup title will only become the fifth English player to achieve the feat.
"As we start our journey towards the 2021 World Cup, the focus over the Quilter Internationals is not only on winning but performance. We have reshaped our game and we will be looking to see which players can bring the plan to life in the intensity of an international match environment," said Middleton.
"With full-time contracts on the horizon and a great season of international rugby in front of us, the challenge and opportunity is there for individuals to stake their claim as a Red Rose."
Vicky Fleetwood, Sarah McKenna and Lydia Thompson will be hoping for their first starts since the 2017 World Cup while this will be the first Test squad selected by Middleton without recently retired Rochelle Clark and full-back Danielle Waterman.
England will face USA, Canada and Ireland on 9th, 18th and 24th November respectively.
England Women squad:
Forwards: Zoe Aldcroft, Sarah Beckett, Jo Brown, Hannah Botterman, Shaunagh Brown, Poppy Cleall, Vickii Cornborough, Lark Davies, Vicky Fleetwood, Sarah Hunter, Heather Kerr, Ellie Mulhearn, Cath O'Donnell, Marlie Packer, Ellena Perry, Abbie Scott.
Backs: Lucy Attwood, Rachael Burford, Katy Daley-Mclean, Abigail Dow, Zoe Harrison, Tatyana Heard, Claudia Macdonald, Sarah McKenna, Leanne Riley, Kelly Smith, Lydia Thompson, Carys Williams.