England international Billy Vunipola has suffered another injury setback as he refractured his arm during the second Test against South Africa in Bloemfontein.
The 25-year-old left the field just before half-time of the game which the red rose team went on to lose 23-12.
Vunipola will leave the squad in South Africa and will head to London for a further reassessment of his injury.
Earlier, a shoulder injury had ruled Vunipola out of the British and Irish Lions tour of New Zealand last year and he also missed the start of the Six Nations 2018 for England when he broke his arm for the first time.
Meanwhile, Mako Vunipola has also returned home for family reasons and Ellis Genge is also ruled out of the final game after he picked up a knee injury during training.
The third and final Test of the series will be played in Cape Town on 23rd June with South Africa having an unassailable lead of 2-0 following their wins in Johannesburg and Bloemfontein.