Saracens lock George Kruis will miss England's final two autumn international campaign against Japan and Australia following a calf injury.
The 28-year-old sustained the injury during the game against All Blacks at Twickenham last weekend where he was replaced by Charlie Ewels in the 66th minute.
Kruis' absence means Eddie Jones is left with Maro Itoje, Ewels, Elliott Stooke and Courtney Lawes as the options for locks in the 30-man squad that has been named for the training camp in Surrey ahead of next weekend's clash against Japan.
The squad features Nick Schonert, Stooke and Joe Cokanasiga in the uncapped player list along with Ted Hill, who is included as an apprentice.
Following the game against Japan next Saturday, Jones' men will end their autumn international series with a clash against Wallabies on 24th November with both the games scheduled at Twickenham Stadium.
Forwards: Charlie Ewels, Jamie George, Dylan Hartley, Alec Hepburn, Ted Hill, Maro Itoje, Courtney Lawes, Zach Mercer, Ben Moon, Nick Schonert, Brad Shields, Kyle Sinckler, Elliott Stooke, Sam Underhill, Harry Williams, Mark Wilson.
Backs: Chris Ashton, Joe Cokanasiga, Danny Care, Elliot Daly, Owen Farrell, George Ford, Alex Lozowski, Jonny May, Jack Nowell, Henry Slade, Ben Te'o, Manu Tuilagi, Richard Wigglesworth, Ben Youngs.